Imaging Core

  • Deep Brain Stimulation DBS imaging Noam Harel
  • Noam Harel Deep Brain Stimulation DBS image
  • Noam Harel 7T MRI image

The University of Minnesota (UMN) Udall Imaging Core is led by Noam Harel, Ph.D. and is based at the University of Minnesota’s internationally renowned Center for Magnetic Resonance Research (CMRR).

Deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD) can be highly effective at improving motor symptoms and enhancing the patient’s quality of life. However, clinical outcomes can vary greatly within- and across-studies. Much of this variability can likely be accounted for by differences in DBS lead location. Using a state-of-the-art, high-field 7 Tesla (T) MRI scanner and capitalizing on the high resolution and enhanced image contrast afforded by high-field MRI, we are developing methods for enhancing the detection and the visualization capabilities of DBS target structures and their surroundings. These new imaging capabilities allow for a direct targeting surgical approach for accurate delivery of the DBS lead into the intended sub-region within the anatomical structure. Furthermore, by combining the postoperative computed tomography (CT) images, the final electrode locations, and its individual contacts, can be accurately determined. Combining several cutting-edge, multi-modal, imaging and computer science visualization techniques we can now create a true comprehensive patient-specific anatomical model of the target region and the associated networks.

 

Core Lead

Noam Harel profile photo
Noam Harel, PhD
Professor, Radiology/CMRR